Seminar “Inference of Inter-Protein Interaction from Co-Evolution sequence data”
Date
Monday, 26 September 2016
Time
12:00 am
Place
University of Barcelona
Faculty of Physics Building
Room 3.20, 3rd floor
Speaker
Dr Andrea Pagnani, Politecnico di Torino (Italy)
Abstract
Interaction between proteins is a fundamental mechanism that underlies virtually all biological processes. Many important interactions are conserved across a large variety of species. The need to maintain interaction leads to a high degree of co-evolution between residues in the interface between partner proteins. The inference of protein-protein interaction networks from the rapidly growing sequence databases is one of the most formidable tasks in systems biology today.
We propose here a novel approach based on the Direct-Coupling Analysis of the co-evolution between inter-protein residue pairs. Concrete examples discussed the bacterial ribosome protein-protein interaction network, the Trp operon. Finally, I will present an interesting application in the field of immunology: the inference of antigen-antibody affinity from Repertoire Sequencing Data.
