Seminar “Molecular models of DNA: can we still learn something… more?”
Date
Wednesday, 14th June 2017
Time
9:30 am
Place
University of Barcelona
Faculty of Physics Building
Room 3.20, 3rd floor
Speaker
Dr Fabrizio Cleri, EMN-Université de Lille (France)
Abstract
The results of record-long (1 microsecond) molecular dynamics simulations of DNA fragment wrapped around a whole histone core (a nucleosome) including double-strand breaks are presented. A recently developed technique allows to calculate the atomic-level stress in such a big, heterogeneous system. In the second part, the molecular model of DNA melting is reviewed, and recent results obtained on mismatch defects on short (25-bp) sequences from microarray techniques are discussed.
